An awareness event organised on the eve of the 'World AIDS Day' at Khalpara area in Siliguri on November 30, 2021 (Photo: AFP/Diptendu DUTTA) -
Testing in humans of an HIV vaccine that uses messenger RNA technology has begun, the biotech firm Moderna and the International AIDS Vaccine Initiative said Thursday (Jan 27).
This Phase 1 trial is being carried out in the United States among 56 healthy adults who are HIV negative.
Despite four decades of research, doctors have yet to develop a vaccine to protect people from the virus that causes AIDS, which kills hundreds of thousands of people around the world each year.
But hopes have been stirred with the success of mRNA technology, which allowed for the development of COVID-19 vaccines in record time, including one from Moderna.
The goal of the vaccine now being tested is to stimulate production of a kind of antibody called "broadly neutralising antibodies," or bnAbs, which can act against the many variants of HIV that are circulating today.
The vaccine is supposed to teach B lymphocytes, which are part of the immune system, to generate these antibodies.
In this trial, participants are injected with an immunogen - a substance that can trigger an immune response - and then a booster immunogen later.
These substances will be delivered with mRNA technology.
"The induction of bnAbs is widely considered to be a goal of HIV vaccination, and this is the first step in that process," Moderna and the IAVI, a research organization, said in a statement.
"Further immunogens will be needed to guide the immune system on this path, but this prime-boost combination could be the first key element of an eventual HIV immunisation regimen," said David Diemert, a lead investigator at one of the four sites where the trial is being carried out, George Washington University in the US capital.
The immunogens used in this trial were developed by IAVI and the Scripps Research Institute, with support from the Bill & Melinda Gates Foundation, the US National Institute of Allergy and Infectious Diseases and Moderna.
A first trial last year tested the first immunogen but without employing mRNA technology. It showed that the desired immune response was triggered in dozens of people taking part in the research.
The next step was to bring in Moderna with its new mRNA technique.
"Given the speed with which mRNA vaccines can be produced, this platform offers a more nimble and responsive approach to vaccine design and testing," the Moderna-IAVI statement said.
"The search for an HIV vaccine has been long and challenging, and having new tools in terms of immunogens and platforms could be the key to making rapid progress toward an urgently needed, effective HIV vaccine," said Mark Feinberg, the CEO of IAVI//CNA
Japan's Finance Minister Shunichi Suzuki wearing a protective face mask delivers his policy speech during the start of an extraordinary session of the lower house of the parliament, amid the coronavirus disease (COVID-19) pandemic, in Tokyo, Japan, Dec 6, 2021. (File photo: REUTERS/Issei Kato) -
A Japanese government panel tasked with reviewing the need for quarterly corporate disclosure requirements aims to draw up a summary report this spring, Finance Minister Shunichi Suzuki said on Friday (Jan 28).
Japanese Prime Minister Fumio Kishida wants to relax quarterly disclosure requirements for companies as part of his pledge to forge a "new capitalism", but implementation is expected to take years, complicating the outlook for one of his key promises.
Quarterly disclosures were made mandatory for firms in 2008 in a move to bring Japan's rules more in line with those of the United States, boosting the Tokyo market's appeal for overseas investors.
The report summary would lay out points that might need to be debated in more detail, setting the stage for a deeper discussion on the quarterly disclosure requirements at the panel, which is overseen by the Financial Services Agency (FSA).
"The revision of quarterly disclosures should be carefully discussed," Suzuki told reporters after a cabinet meeting.
"Under the new capitalism (plan) of the Kishida government, we think it's important for firms to emphasise long-term growth rather than short-term profitability and to manage benefits of not only shareholders but of various stakeholders, such as workers," Suzuki said.
The earliest the government can submit legislation to parliament to change the quarterly disclosure requirements will be in 2023, and the earliest date new rules can be applied is 2024, government officials told Reuters last October//CNA
Britishvolt to develop batteries for new Lotus electric sports car -
Britishvolt said on Friday it will develop batteries for a fully-electric sports car in partnership with British carmaker Lotus, the first publicly-announced customer for the electric vehicle (EV) battery startup.
Britishvolt said the research and development that will go into developing battery cells for a high-performance sports car for Lotus will ultimately trickle down to benefit battery cells for more affordable, mainstream EVs.
Lotus, which is owned by China's Geely and Malaysia's Etika Automotive, has said it hopes to sell only fully-electric models by 2028.
The carmaker will also expand its range to include high-end electric saloons and sports-utility vehicles.
"Lotus is delighted to be collaborating with Britishvolt to develop new battery cell technology to showcase the thrilling performance that a Lotus EV sports car can deliver," Lotus managing director Matt Windle said in a statement.
Carmakers are racing to develop EVs ahead of looming fossil-fuel car bans in Europe and China.
That poses challenges for sports cars and supercars, which need a great deal of sustained power without lots of additional battery weight.
"Lotus is a performance brand with an ambitious plan," Britishvolt executive chairman Peter Rolton told Reuters during a visit to the construction site for Britishvolt's planned battery plant site in the northern English town of Blyth, a large former coal storage site overlooking the North Sea.
"In order for that to work, they need to have performance that goes with the vehicle and you won't get that from a standard battery."
Rolton said Lotus was the first in a number of customer announcements Britishvolt would make in the coming weeks, including for high-performance vehicles, mainstream EVs and electric commercial vehicles that will require durable, long-lasting batteries.
Last week Britishvolt secured UK government backing for its Blyth plant, unlocking 1.7 billion pounds ($2.28 billion) in private funding from logistics real estate investor Tritax and investment firm abrdn plc.
When the 3.8 billion pound, 45 gigawatt-hour (GWh) plant is fully operational in 2027 it should be able to produce battery packs for over 450,000 EVs annually//CNA
FILE PHOTO: International Monetary Fund logo is seen outside the headquarters building during the IMF/World Bank spring meeting in Washington, U.S., April 20, 2018. REUTERS/Yuri Gripas -
The Bank of Japan should consider further steps to make its ultra-easy monetary policy more sustainable, such as steepening the yield curve by targeting a shorter maturity than the current 10-year yield, an International Monetary Fund executive said.
Such a move would be on top of steps the central bank took in March last year to mitigate the side-effects of prolonged easing, such as allowing 10-year yields to move more widely around its 0per cent target.
The BOJ must clearly communicate that the move would be aimed at enhancing the effect of its ultra-easy policy, not at withdrawing stimulus, said Odd Per Brekk, deputy director of the IMF's Asia and Pacific Department.
"Unlike in other advanced economies, we see inflation in Japan over the next few years moving in the 1per cent range, which is below the BOJ's target," he said.
"This means that the BOJ should continue its accommodative monetary policy stance," he told Reuters in an interview conducted on Thursday.
Under yield curve control (YCC), the BOJ guides short-term interest rates at -0.1per cent and the 10-year bond yield around 0per cent via huge asset buying to fire up inflation to its 2per cent target.
While low borrowing costs have helped companies, they have been criticised for crushing the margin financial institutions earn from lending and draining bond market liquidity
"We think YCC has been successful. It has worked well. But we have also seen some adverse side-effects on the financial sector," Brekk said.
Building on the steps taken in March, the BOJ could make its stimulus programme more effective by shifting the target to a shorter duration than the current 10-year yield, he said.
"Now is not the time to do this. It's something to consider if you need to strengthen policy or respond to shocks" by ramping up stimulus, Brekk said.
While the recent rise in food and energy costs will prove temporary, Japan will see inflation momentum build up this year as consumption rebounds and allows companies to pass on some of the higher costs to households, he said.
But inflation will remain short of the BOJ's 2per cent goal in the medium term, requiring the bank to maintain current stimulus.
"To get inflation sustainably to the 2per cent target requires a broader policy strategy" consisting not just of monetary stimulus but flexible fiscal policy and measures to boost Japan's potential growth, Brekk said//CNA