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 Iran's supreme leader on Monday gave his full backing to security forces confronting protests ignited by the death of Mahsa Amini in custody, comments that could herald a harsher crackdown to quell unrest more than two weeks since she died.

In his first remarks addressing the 22-year-old woman's death after being arrested for wearing clothes deemed un-Islamic, Ayatollah Ali Khamenei said her death "deeply broke my heart" and called it a "bitter incident" provoked by Iran's enemies.

"The duty of our security forces, including police, is to ensure the safety of the Iranian nation...The ones who attack the police are leaving Iranian citizens defenceless against thugs, robbers and extortionists," Khamenei said.

Security forces, including police and the volunteer Basij militia, have been leading a crackdown on the protests, with thousands arrested and hundreds injured, according to rights groups, which put the death toll at over 130.

Iranian authorities have reported many members of the security forces killed during the unrest, which has spiralled into the biggest show of opposition to Iran's authorities in years, with many calling for the end of more than four decades of Islamic clerical rule.

Khamenei said security forces had faced "injustice" during the protests. "In recent incidents, it is above all security forces including the police and Basij, as well as the people of Iran, who were wronged," he said.

Iranian authorities have reported many members of the security forces killed during the unrest, which has spiralled into the biggest show of opposition to Iran's authorities in years, with many calling for the end of more than four decades of Islamic clerical rule.

Khamenei said security forces had faced "injustice" during the protests. "In recent incidents, it is above all security forces including the police and Basij, as well as the people of Iran, who were wronged," he said. (Reuters)